Introduction

Tacalyx is a biopharmaceutical company developing innovative therapeutics to target tumor-associated carbohydrate antigens (TACAs). To strengthen our team in Berlin-Adlershof, we are seeking an experienced, enthusiastic, and self-driven Senior Scientist/Group Leader (m/f/d) Antibody and Protein Biochemistry.

The major focus of this position is the design, expression, characterization and chemical modification of antibodies and other proteins.

Your Tasks and Responsibilities

Molecular cloning and expression of recombinant proteins in prokaryotic and mammalian cells
Organization and conduction of antibody generation projects (e.g., phage display, hybridoma, B-cell cloning, etc.)
Planning and management of the production of antibodies in different formats (e.g., ADC, bispecific)
Design and performance of antibody binding assays (e.g., ELISA, Western blot, tailored arrays, SPR)
Chemical and enzymatic modification of mAbs (e.g., mAb fragmentation, coupling to solid supports or proteins)
Characterization of antibody preparations (e.g., integrity, activity, stability)
Preparation of scientific reports and maintenance of the current state of scientific literature
Collaboration in project teams working on the development of antibodies towards first in human studies
Management and monitoring of projects with external parties (e.g., CROs, academic groups)

Your Profile

PhD in the field of biological sciences with recent, extensive research laboratory experience
2+ years of relevant experience after your PhD in academics or industry
Hands-on experience with techniques relevant for recombinant protein expression
Knowledge about antibody production in mammalian cells is expected (experience with ADC or bispecifics is a plus)
Strong background in antibody technologies and biochemical characterization, knowledge of antibody humanization would be a plus
Physical experience with different protein chromatography techniques is mandatory (knowledge in HPLC-based method development would be an asset)
Knowledge of carbohydrate biology would be an asset
A high level of communication in English and a work permit for Germany (for non-EU applicants) are mandatory

We Offer

A permanent position with a competitive salary as well as excellent opportunities for professional and personal development
A diverse, international workforce with a dynamic working environment that fosters creativity, innovation and teamwork
Annual bonus payment depending on target achievement
Regular company and team events
Free “Job ticket” (allows the holder to use local public transport anywhere in Germany)

Contact

If you are self-driven, interested to work in a professional field at the forefront of science and your background and personal experience fit this profile, please apply via email with the following documents in English or German:

Cover letter (including the earliest possible starting date, as well as your salary expectation)
Curriculum vitae (CV)

Apply now

Full-Time , Permanent

Specialist

Updated at 03/03/2025

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