The IUF - Leibniz Research Institute for Environmental Medicine investigates the molecular mechanisms through which particles, radiation and environmental chemicals harm human health. The main working areas are environmentally induced aging of the pulmonary system and the skin as well as disturbances of the nervous and immune system. Through development of novel model systems, the IUF contributes to the improvement of risk assessment and the identification of novel strategies for the prevention / therapy of environmentally induced health damage. The core unit model development is offering a position for a

Cell Biologist (f/m/d) (PhD student).

The position is to be filled at IUF as of February 1st, 2025

Activities and responsibilities

We are seeking a highly motivated PhD candidate to join our research team for an exciting project focused on understanding the fundamental processes of early human development in induced Pluripotent Stem Cells (iPSCs). The project, entitled \"Whole Genome CRISPR Screening to Identify Determinants of Germ Layer Formation,\" aims to uncover key regulators of germ layer specification using cutting-edge genomic technologies.
The project aims to enhance our understanding of the genetic and molecular mechanisms governing early human development, with potential implications for regenerative medicine and developmental biology. The successful candidate will have the opportunity to work with state-of-the-art technologies and contribute to the field of stem cell biology and developmental genetics.

Qualification profile

We seek a highly motivated candidate (f/m/d) with a solid background in cell biology. Expertise in standard molecular biology techniques, cell culture and ex-vivo models is critical. Previous work with genome editing is a plus. The candidate is required to have strong skills in English and German. Motivation to work independently and be responsible for the daily management of his/her/their research project in coordination with other members of the group is expected. The candidate will also be actively involved in the training and co-supervision of other group members and students.

ROLE RESPONSIBILITIES

The individual should apply their significant expertise in stem cell biology, cell culture and organoids, molecular biology-based techniques, along with their understanding such as plasmid cloning, gene editing, AAV vector production, electroporation, qPCR, RT-PCR, nucleic acid extraction and cloning, gel electrophoresis, macromolecule blotting and probing and mouse handling is highly desirable.
Participate in the development and qualification of assays. Independently analyze data and provide conclusions. Critically evaluate own and others results and offer insights based on process and product understanding to help solve problems.
Contribute to patents, regulatory documents or manuscript as required.
Read scientific and technical literature in order to bring new and improved procedures to the laboratory, and to broaden understanding of disciplines outside area of training. Utilizes all appropriate experimental design methods needed for work in area of specialization. Conduct literature searches and apply knowledge to the approaches taken.
Participate in scientific discussion with colleagues through informal and formal scientific seminars and meetings.

EDUCATION AND EXPERIENCE

Experience with cell culture, iPSCs, ex-vivo models, organoids are highly preferred.
In depth understanding of iPSCs, organoids and co-culture systems.
Demonstrated competency in immunohistochemistry, western blotting and DNA cloning.
Experience with sequence analysis using bioinformatics and genomics.
Demonstrated proficiency in Microsoft Office, including Word, Excel, and PowerPoint.
Strong verbal and written communication skills are required (English and German).

DESIRED KEY COMPETENCIES

Self-motivated, highly organized, meticulous hands-on habits, keen to accuracy, and attention to detail.
Positive can-do attitude, responsible and responsive, and maintain a high degree of ethical standard and trustworthiness.
Strong quantitative and analytical skills, able to reach rational conclusions through complex processing of information.
Energized by accomplishments and excellence in the workplace. Competent of high performance in independent work and coordinated efforts in implementing group projects.
Maintain timely documentation of laboratory work and keep well organized records.
Evaluate results, analyze and interpret data to prepare projects updates, meeting presentations and research reports for documentation and publication.

We offer

The position is limited for to 2 years with the option of one year extension. The weekly working time totals 25 hours and 54 minutes. Remuneration is given in accordance with the provisions of the collective agreement for the employees of the states (TV-L). Salary will be according to TV-L (E13).

We promote equal opportunities and diversity. Women are particularly invited to apply and will be given preferential consideration in accordance with the LGG NRW. Applications from people with severe disabilities and their peers are also expressly encouraged.

Please address your application (incl. letter of motivation, CV, references, qualification certificates), preferably electronically, to email:
Dr. Andrea Rossi
IUF - Leibniz-Institut für umweltmedizinische Forschung
c/o Personalstelle
Auf’m Hennekamp 50
40225 Düsseldorf
email

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Apply now

Part-Time , Temporary

PhD Project

Updated at 11/19/2024

While applying for the job please refer to jobvector and use the following reference number: Cell Biologist GEMD