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Postdoc Position (f/m/x) Role of Transposable Elements in Shaping Immune Responses in HIV-1 Infection

The Leibniz Institute of Virology (LIV) is an independent research institution for basic biomedical research. As a foundation under civil law and member of the Leibniz Association, the Institute occupies a leading position both nationally and internationally.

The BMBF research group “Genomics of Retroviral Infection”, headed by Dr. Ulrike Lange, focuses on the biology of human exogenous and endogenous retroviruses and on development of approaches to control retroviral infections. The group uses a wide range of experimental methods combined with computational biology approaches to address research questions that span from basic to translational science. In recent work, we have characterized the signature of human endogenous retrovirus (HERV) activity at locus-level resolution in primary T cells (Hamann et al., 2023, BMC Medical Genomics). We are currently actively exploring how this signature is impacted upon in HIV-1 infection, which has been reported to induce global HERV activation. The project will focus on functional studies to dissect HERV-regulated or -modulated pathways in infected and bystander CD4 T cells, to better understand how transposable elements are shaping immune responses in HIV-1 infection. The project will involve experimental laboratory work, including a range of molecular biology techniques, genetic engineering / KD / KO studies in primary T cells and generation and analysis of transcriptomics and epigenomics datasets amongst other.

We are looking for a highly motivated, ambitious, and team-oriented candidate for a postdoc position (f/m/x) - the role of transposable elements in shaping immune responses in HIV-1 infection.

Your Tasks:

Conducting and shaping a research project on the topic of TEs in HIV-1 infection
Working as independent researcher with accountability towards the research project
Integrating into the research team and providing support for junior members / students
Presenting research findings at national and international level
Developing future research projects and draft manuscripts

Your profile:

Solid expertise in human immunology and experimental laboratory work
Expertise in transposable element biology and HIV-1 virology is an asset but not required
Strong commitment, team spirit, very good communication and organizational skills, and ability to work in an independent and flexible manner
PhD degree in the life sciences
Very good English language skills (oral and written)

What we offer:

Working as part of a highly motivated team in a state-of-the-art, international research environment with excellent core facilities
Remuneration according to E 13 TV-AVH (Hamburg Employment Law Association Collective Agreement, comparable to TVöD [Civil Service Collective Agreement]), including company pension scheme and 30 days of annual vacation
Further training opportunities, including subsidized English and German courses at the institute
Health protection offers at the institute (in cooperation with voiio GmbH)
Flexible, family-friendly working hours
HVV-Deutschlandticket subsidy
Canteen use subsidy

The position is initially limited for two years with starting date in the 1st quartile of 2025.

The LIV is certified with the TOTAL E-QUALITY distinction and promotes work-life balance and professional equality between employees of all gender and genders. Severely disabled persons will be given preferential consideration if their suitability, qualifications, and professional performance are otherwise equal.

Your application should include a letter of motivation, CV, short description of previous research projects and technical expertise, names and contact details of two referees, and your certificates. We look forward to receiving your application in English language until November 15, 2024. Until the position is filled, applications received at a later date may be considered.

Would you like to shape the future with us? Then we look forward to receiving your application!

Contact for requests:

Dr. Dr. Ulrike Lange (email)

Leibniz Institute of Virology (LIV) | Martinistraße 52 (N63) | 20251 Hamburg | www.leibniz-liv.de

Apply now

Full-Time , Temporary

Postdoc

Updated at 11/04/2024

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