Cell Biologist (f/m/d) (PhD student), Project EpiDish

We are seeking two highly motivated PhD candidates to join our research team for an innovative Leibniz-funded project, EpiDish, which investigates the impact of environmental pollution on human sensory functions, with a specific focus on taste perception and nutrient sensing. This project, titled Modeling Pollution-Induced Effects on Taste and Nutrient Sensing Using Taste Bud and Stomach Organoids, aims to uncover the cellular and molecular mechanisms by which air- and foodborne pollutants may impair taste perception, disrupt nutrient sensing, and influence health outcomes related to appetite regulation and calorie intake.

The project involves cutting-edge research methods, including organoid models derived from human induced pluripotent stem cells (iPSCs). By generating 3D structures that mimic tongue and stomach tissues, we will assess how pollutants like traffic-related particulate matter and heavy metals alter taste receptor expression, signaling pathways, and nutrient uptake.
This will be paired with sensory trials and data from the NaKo cohort to explore associations between urban pollution exposure and dietary behaviors in different age groups.

The successful candidates will have the opportunity to work with advanced in-vitro models and exposure systems, integrating cellular biology with epidemiological research to address critical questions in public health. This research has the potential to promote healthier eating, reduce malnutrition, and improve well-being by providing evidence for mitigating the effects of pollution on sensory health.

We seek a highly motivated candidate (f/m/d) with a solid background in cell biology. Expertise in standard molecular biology techniques, cell culture and ex-vivo models is critical. Previous work with genome editing is a plus. The candidate is required to have strong skills in English and German. Motivation to work independently and be responsible for the daily management of his/her/their research project in coordination with other members of the group is expected. The candidate will also be actively involved in the training and co-supervision of other group members and students.

The position is limited for to 2 years with the option of one year extension. The weekly working time totals 25 hours and 54 minutes. Remuneration is given in accordance with the provisions of the collective agreement for the employees of the states (TV-L). Salary will be according to TV-L (E13).

We promote equal opportunities and diversity. Women are particularly invited to apply and will be given preferential consideration in accordance with the LGG NRW. Applications from people with severe disabilities and their peers are also expressly encouraged.