The Department of Pediatric Oncology, Hematology and Clinical Immunology
(Director: Prof. Dr. A. Borkhardt)
is looking for a
Postdoctoral Researcher (f/m/x) with
Bioinformatics / Computational Biology background - E 13 TV-L
at the earliest possible date. The position is available for a limited period of 3 years (extension possible).
Our department specializes in diagnosing and treating hematological, oncological, and immunological disorders in children and adolescents. We have extensive expertise in inborn errors of immunity, attracting both national and international patient referrals. Our sequencing lab performs integrative analysis of complex data sets generated by our in-house Next Generation Sequencing facility. Current projects focus on investigating cancer predisposition syndromes using SNP arrays, trio-whole exome/genome sequencing (NextSeq550, Illumina), long-read whole genome sequencing (Sequel II, PacBio), and whole genome mapping (Saphyr, Bionano Genomics).
We are seeking a postdoctoral researcher with expertise in next-generation sequencing techniques to join our interdisciplinary team of biologists, medical doctors, and bioinformaticians. The goal is to enhance diagnostics for patients with inborn errors of immunity. Responsibilities include data processing, maintaining and further developing existing analysis pipelines into routine processes for identifying patients with known genetic diseases. Additionally, the successful candidate will analyze complex data sets (genome, exome, transcriptome, bulk, single-cell data) to uncover the genetic causes of patients with unidentified immune disorders.
Your profile:
- PhD in a relevant field (e.g., computer science w biological background, bioinformatics, life sciences)
- Excellent written and verbal communication skills in English (German is desirable but not required)
- Experience in generating and systematically evaluating NGS data, especially within a clinical framework
- Proficiency in bioinformatic data analysis of bulk, single-cell, and spatial gene expression, mutations, and related platforms
- Experience in guiding and coordinating employees involved in data evaluation or wet-lab work
- Proficiency with UNIX operating systems, including HPC environments
- Programming experience in languages such as Python, Bash, C, Java, or Rust (experience with database programming is desirable)
- Strong knowledge of statistics and R (experience with Bayesian statistics and network models is desirable)
- Solid understanding of cancer biology and immunology
We offer:
- An exciting position within a collaborative team of bioinformaticians, biologists and physicians
- Access to samples from patients with rare immunological disorders
- Opportunities to participate in national and international research networks
- Attractive prospects for further training and professional development
- Corporate benefits (mitarbeiterangebote / wellhub®)
- Enjoy a high quality of life in Düsseldorf and the surrounding Rhein-Ruhr area, Germany's largest metropolitan region, renowned for its vibrant cultural scene (especially art), numerous sports activities, and diverse international community.
For further questions please contact Priv.-Doz. Dr. Sujal Ghosh:
email